Gas-bubbles
We investigate the interaction between sound waves and gas-bubbles, to elucidate the ability of gas-bubbles to serve as efficient theranostic probes at a targeted site. Upon excitation with ultrasound, these contrast agents expand and contract, providing a unique mechanism for noninvasive ultrasound therapy.
Brain therapy
The delivery of therapeutics into the brain is limited due to the innate blood brain barrier, which poses an obstacle for effective drug delivery. We combine low-energy ultrasound with intravenously injected microbubbles to open the blood brain barrier in a noninvasive and localized manner, and to enable drug delivery.
Cancer therapy
We develop new therapeutic platforms where gas-bubbles coupled with low frequency insonation are used as a mechanism for enhanced vascular permeability, which enables drug and gene delivery into tumors.
Beam shaping ultrasound imaging
We are developing optically-inspired ultrasonic techniques for the establishment of new ultrasound imaging methods, and for enhancing ultrasound imaging capabilities beyond what was feasible in the past. Specifically, we are interested in time multiplexing super-resolution, extended depth of field, obstacles bypassing and ultrasound tomography.
3D ultrasound imaging
Conventional transducers are 1D, and thus provide 2D ultrasound images. Therefore, since a 1D array is used to image a completed 3D anatomic volume, 2D ultrasound is inherently incomplete. An innovative possibility now exists due to a new 2D matrix array transducer, which enables 3D ultrasound imaging.
