We develop noninvasive medical ultrasound technologies for diagnostics, monitoring, and therapy for clinically relevant problems. Our research is highly multidisciplinary, combining engineering, physics, biology, chemistry and medicine. We utilize the unique ability of sound waves to penetrate deep into the body, in some cases even through an intact skull, and couple it with gas-bubbles. These bubbles are efficient theranostic probes that can be used for simultaneous imaging and controlled therapy at a targeted site. We develop enhanced ultrasound-mediated gene delivery methods, noninvasive ultrasound surgery, and safe and precise blood brain barrier opening for brain therapy. In parallel, we are developing optically-inspired ultrasonic techniques for overcoming current limitations in ultrasound imaging. Current interests include 3D ultrasound, super-resolution, image processing and machine learning.